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Ethical principles of the study ensured compliance with European Directive 010/63/E, the Law on Amendments to Animal Protection Act (Official Gazette 37/13, the Animal Protection Act (official Gazette 135/06), Ordinance on the protection of animals used for scientific purposes (Official Gazette 55/13), FELASA recommendations, and recommendations of the Ethics Committee, School of Medicine, University of Zagreb

Concentrations of pyruvate which maintain PDH in the active form are sufficiently high so that, in energy-rich cells, the allosterically down-regulated, high K m form of PDH is nonetheless capable of converting pyruvate to acetyl-CoA

Collectively, microglia promote inflammatory cycles via the NLRP3 pathway, while astrocyte dysfunction exacerbates glutamate toxicity and BBB dysregulation

70 HengB.GunasegaranB.KrishnamurthyS.BustamanteS.PiresA